Wednesday, July 28, 2010

From the depression to… the fracture?



Taking antidepressant originally from the family of Serotonin Reuptake Inhibitors (IRS) would be well associated to the decrease of the bone mineral density in aged persons, with the consequence that it will rise the risk of fractures.The Professor Susan Diem, from Minnesota University, have monitored 2722 aged womens under 78.5 years old. Two hundred of them are taking this kind of antidepressant.
With her team, she measured the bone mineral density of all the patients, at the level of the hip-bone.
The results are: the bone density of these womens were lower than womens which didn’t use the antidepressant or that didn’t use at all the antidepressant.
For the professor, these last generation’s antidepressants which interfere with the function of osteoclast and osteoblast, weaken the bones.
Source: Archives of International Medicine

Friday, July 23, 2010

The real top ten iPhone medical apps...

There’s been a flurry of “Top Ten (free) Medical iPhone Apps” lists gracing the homepages of a number of health blogs and publications this week. Because of the iTunes’ AppStore’s popularity, trying to pin down the Top Ten Free Apps in a given category is like trying to shoot a moving target. If you believe recent studies, chances are anyone who downloaded one of these apps last week won’t be using it for much longer.
That said, the headline of this post is a bit tongue-in-cheek, because by tomorrow or even by tonight this list will probably be dated, too. Furthermore, I guarantee you these are not the true top 10 free iPhone Medical Apps.  There is no easy way to determine whether Apps are worth the time to explore right now and no authoritative source for mHealth app reviews. These are just the ones that happen to be getting the most downloads currently.
But for the sake of at least timely reporting: Here are the real top ten iPhone medical apps, which include one new app that was not included on other lists and also sees some rank-shifting:
1. Epocrates – This app lets users view continually updated clinical data, check for drug-drug interaction, identify pills by physical characteristics and perform medical calculations such as BMI and GRF. We wrote about it a few weeks ago.
2. Skyscape Medical Resources – Skyscape’s app includes resources like RxDrugs, evidence-based clinical information on conditions and symptoms, Archimedes Medical Calculator, and MedAlert drug information.
3. EyeChart – The Snellen Eye Chart is an eye chart for testing visual acuity. The app instructs users to hold the iPhone eye chart about four feet away instead of the typical 20 feet.
4. MedCalc (medical calculator) – MedCalc is a medical calculator that gives the user access to an array of medical formulas and scores.
5. Taber’s Medical Dictionary – Taber’s Medical Dictionary app includes more than 60,000 terms, 1,000 photos and 600 Patient Care Statements. The app also offers definitions and other resources, including nutrition and alternative therapy, coverage, medical abbreviations, and units of measurements.
6. Davis’s Drug Guide – Davis’s Drug Guide provides info on more than 5,000 trade name and generic drugs. This app includes info on other drug/natural/food interactions, appendices with dose calculations, customizable bookmarking and patient safety infor.
7. Eponyms (for students) – Eponyms displays a short description from more than 1,600 medical eponyms (ex. Sheehan’s syndrome, Virchow’s node).
8. ShyBladder – ShyBladder helps those who have trouble getting things started in the restroom. The app offers three different sounds of running water. (Maybe others were too afraid to include this on the list? Seriously, its number 8.)
9. STAT ICD-9 LITE – STAT ICD-9 LITE provides all 13,677 ICD-9-CD diagnosis codes to the user’s iPhone. 
10. PubMed On Top Lite – PubMed On Tap Lite searches PubMed to provide and display reference information. The app includes EZproxy support, internal Web browser, option to email results in text or RIS form, advanced search options andthe ability to store and recall recent searches.
So which app is no longer officially in the top 10 because of ShyBladder? Cardio Calc. This app designed help manage patients with cardiovascular disease or hyperlipidemia by providing Framingham and Reynolds Risk scores as well as CHADS2 score.
Those are the most popular. Which Apps not listed here should be on the list but aren’t?
Related Articles:
The image above is a series of screenshots from the MiM iPhone App, which didn’t make the list.
Yet another iPhone Pill Tracker App: iPills
ABG iPhone App analyzes blood glucose levels
Don’t forget Diagnosaurus–now on iPhone, too
Edge Health Solutions has a suite of remote office management apps for doctors and dentists
iTMP has a number of fitness apps that sync up to their wireless bridge and biometric sensors
A.D.A.M. has an iPhone App, too

Friday, July 9, 2010

Sunlight alone does not cause skin cancer: The truth you've never been told



We've all been told that sunlight causes skin cancer. This message has been drilled into our heads for so long that most people actually believe it. But what if this "truth" was actually a medical myth? What if dermatologists and health experts didn't know the whole story? What if their explanations about sun exposure and skin cancer were too simplistic and outdated?


Today, I've released a new tell-all video that exposes the lies of dermatology and the cancer industry while explaining the truth about sunlight, vitamin D and skin cancer. That video is available now on the new video site NaturalNews.TV: 

 



Here's what you'll learn about sunlight exposure, skin cancer and vitamin D in this free video:

• Why tanning booths can be GOOD for your health and actually prevent cancer!
• The origins of the term "red neck" and what this teaches us about the true causes of sunburn.
• Why sunlight alone does not cause sunburn: There's another variable that's just as important!
• Why sunlight exposure could reduce cancer rates in America by nearly 80%.

• Why the cancer industry continues to propagate myths about sun exposureand skin cancer.

• How to build up your own "internal sunscreen" by changing what you eat!
• Why sunscreen products are terrible for your health and may actually cause skin cancer.
• Why dark-skinned people need far more sunlight exposure than fair-skinned people to prevent cancer.
• How to spend more time in the sun without getting burned, even without using sunscreen.
• Why cancer tumors grow during the winter months (and how to stop tumor growth in just minutes a day).
• Why Asian women are endangering their health by avoiding sunlight exposure in order to keep their skin more fair (pale).
• Why cancers are more serious in African Americans than Whites. (And why they're not being told the truth by the cancer industry...)
• Why working (and living) indoors will turn you into "a ticking time bomb" of disease.
• Why the effort to censor the truth about sunlight as medicine is a dark, evil scheme dreamed up by for-profit cancer institutions and drug companies who profit from the suffering of human beings.
• Why the cancer industry wants you to live in darkness and be afraid of light, knowledge and illumination.

 And then do your own research! Verify everything for yourself, and you'll see that everything revealed in this video is true.


 

Thursday, July 8, 2010

Higher Anxiety, Depression Among Women May Have Basis in Cell Signals

This is the first evidence for sex differences in how neurotransmitter receptors traffic signals," said study leader Rita J. Valentino, Ph.D., a behavioral neuroscientist at The Children's Hospital of Philadelphia. "Although more research is certainly necessary to determine whether this translates to humans, this may help to explain why women are twice as vulnerable as men to stress-related disorders.
The research appears online in Molecular Psychiatry. The study's first author is Debra A. Bangasser, Ph.D., a fellow in Valentino's laboratory. It has long been recognized that women have a higher incidence of depression, post-traumatic stress disorder, and other anxiety disorders, said Valentino, but underlying biological mechanisms for that difference have been unknown. Her research focuses on corticotropin-releasing factor (CRF), a hormone that organizes stress responses in mammals. Analyzing the brains of rats that responded to a swim stress test, Valentino's team found that in female rats, neurons had receptors for CRF that bound more tightly to cell signaling proteins than in male rats, and thus were more responsive to CRF. Furthermore, after exposure to stress, male rats had an adaptive response, called internalization, in their brain cells. Their cells reduced the number of CRF receptors, and became less responsive to the hormone. In female rats this adaptation did not occur because a protein important for this internalization did not bind to the CRF receptor. "This is an animal study, and we cannot say that the biological mechanism is the same in people," said Valentino, adding that other mechanisms play a role in human stress responses, including the actions of other hormones. However, she added, "researchers already know that CRF regulation is disrupted in stress-related psychiatric disorders, so this research may be relevant to the underlying human biology." Furthermore, said Valentino, much of the previous research on stress disorders in animal models used only male rodents, so important sex differences may have gone undetected. "Pharmacology researchers investigating CRF antagonists as drug treatments for depression may need to take into account gender differences at the molecular level," she said. The National Institutes of Health provided funding support for this study. Co-authors with Valentino and Bangasser were Andre Curtis, Ph.D., Thelma T. Bethea, Ioannis Parastatidis, M.D., and Harry Ischiropoulos, Ph.D., all of The Children's Hospital of Philadelphia; and Elisabeth J. Van Bockstaele, Ph.D., of the Farber Institute for Neurosciences of Thomas Jefferson University.

Monday, July 5, 2010

Are you at risk for osteoporosis? Make the one minute IOF test.



We was reading today that Gwyneth Paltrow, only 37 and suffering from osteopenia is now trying to focus her celebrity attention on the incidence of low bone density among younger women.

Unfortunately, this “silent disease” is usually not diagnosed on time and people should recognize whether they have risk factors for osteoporosis and should take personal responsibility for their bone health.

Osteoporosis, which literally means "porous bone", is a disease in which the density and quality of bone are reduced. As the bones become more porous and fragile, the risk of fracture is greatly increased. The loss of bone occurs "silently" and progressively. Often there are no symptoms until the first fracture occurs.

The diagnosis of osteopenia, or low bone density, is usually made after receiving a DXA (“Dual Energy X-ray Absorptiometry”) scan. Such scans are rarely done on women younger than age 50. The exception to this rule would be if the woman has a medical condition known to interfere with bone density. Health issues with known bone impacts can include: high thyroid hormone levels, type 1 diabetes, Cushing’s disease, rheumatoid arthritis, excess cortisol and a greater than three-month use of oral (not inhaled) corticosteroids.
Some of us have had low bone density much of our lives, usually the result of genetics. Other contributing factors can include:
·         Being thin with a body mass index (BMI) less than 21 (e.g., 5’6” and 128 pounds).  (Check your own BMI with the WebMD BMI Plus Calculator.)
·         Current smoker
·         Daily alcohol intake of more than 8oz. wine, 2 oz. of liquor or 24 oz. of beer
·         Low vitamin D levels, often coupled with low calcium intake


Not everyone with low bone density goes on to develop osteoporosis and bad fractures. Bone density is just one factor involved in fracture risk. Some women with low bone density never have a fracture. This might be attributable to good micro-architecture of the bone, or developing muscular strength to help stabilize bones and thus prevent falls.
The age of the woman with low bone density also matters. Two women with the same degree of osteopenia, one aged 50 and the other 70, will have different risks of hip fracture. If there were no added risk factors, and both women had the same osteopenia DXA score of -1.5, the 50-year-old would have a 10-year risk of hip fracture of 0.4%. The 70-year-old would have a 10-year risk of 1.4%. Alas, there is not as much data about low DXA scores in younger women, but we assume that a 40-year-old would have an even smaller risk. This is why most younger women are not started on prescription medications for osteopenia.

Generally, prescription medication to prevent bone loss is reserved for older women and/or those with DXA scores lower than -2.5. Adequate vitamin D intake is something that most of us can improve upon. While the current RDA for Vitamin D is 400 mg/day, most experts believe that the RDA should be at least 800 mg/day for adults.

Links: